Nitin Khanna, CEO of Mergertech, a Mergers and Acquisitions advisory company that provides tech consulting services through global relationships and quality expertise from its team. The dedicated entrepreneur got his start working at Oracle and in paper manufacturing after graduating from Purdue. The Portland-based entrepreneur has endured a long road to success while simultaneously pursuing his passions.
Learn about the hormonal causes of skin aging and how to correct them with Renew Youth’s topical estrogen cream.
Are you concerned about the health and appearance of your skin? You’re not alone. Many women struggle with skin changes that make them look and feel older than they’d like. An overwhelming variety of products that claim to solve this problem are available, but can you really count on any of them to work?
It all depends on the ingredients in the product and the root cause of your skin changes. To make the best choice for your skin, you need accurate information from a source you can trust—such as Renew Youth.
At Renew Youth, we specialize in helping women find solutions to the myriad changes that affect their bodies during menopause—including skin changes. With nearly 20 years of experience in better aging treatments for women, you can trust us for reliable information about skin aging as well as safe and effective products that can help you reduce and even prevent signs of skin aging.
The Structure of Healthy Skin
Firm, smooth, healthy, youthful-looking skin requires three main elements: moisture, collagen, and elastin. Moisture comes from natural skin oils and from compounds like hyaluronic acid, which help keep skin cells plump and hydrated. Collagen, which is actually the most abundant protein in the body, is responsible for creating the structure that holds various tissues in the body together. Within the skin, collagen forms the network that new cells attach to, keeping skin firm and tight. Elastin is another type of protein found in skin. It is responsible for giving skin its resiliency so that it springs back into shape when pressed or pulled.
How Aging Affects Skin
Over time, a variety of environmental, dietary, and hormonal factors work together to disrupt the three elements of healthy skin—moisture, collagen, and elastin—and cause visible signs of skin aging such as wrinkles, sagging, discoloration, and age spots. Collagen in particular will be lost at a rate of between 1 and 1.7 percent per year starting in your 20s.
Here are some of the most important factors to consider when it comes to skin aging:
UV Rays: Sun damage is a leading contributor to skin aging. UVA rays are especially harmful as they can create free radicals that cause collagen and elastin to break down. In addition, UV exposure can cause skin to take on a dull or blotchy appearance due to discoloration and dehydration.
AGEs: Sugars in your diet can react with amino acids in your body in a process called glycation. The resulting Advanced Glycation End-products (AGEs) will trigger an immune response as your body struggles to get rid of them. When you eat lots of sugar and end up with lots of AGEs, the immune response can cause significant damage to proteins such as collagen.
Smoking: Nicotine and other chemicals in cigarette smoke cause premature skin aging in two main ways. They damage collagen, and they also interfere with the delivery of oxygen and nutrients to skin so that it can’t heal and renew itself properly.
Hormone Decline: A healthy balance of estrogen, progesterone, testosterone, and thyroid is vital for healthy skin. Growth hormone is also needed to help repair and rejuvenate skin. Unfortunately, all of these hormones can become unbalanced with age. Estrogen and progesterone in particular will decline sharply at menopause, which is why many women experience new or accelerated signs of skin aging at this time. Common menopause-related skin changes include thinning skin, dry skin, itchiness, loss of elasticity and volume, and more wrinkles.
Types of Anti-Aging Creams
The variety of anti-aging creams on the market today can be really overwhelming. Different products will deliver varying degrees of improvement, depending on which of the top causes of skin aging they target. The main types of active ingredients you will find in all anti-aging skin creams include:
Antioxidants: Free radicals, or unstable oxygen molecules, are a key culprit in the formation of wrinkles. Numerous products make use of various antioxidants to help destroy free radicals and prevent them from breaking down skin cells and damaging collagen and elastin. Common antioxidant skin cream ingredients include retinol, Vitamin C, Vitamin E, CoQ10, green tea extract, and grape seed extract.
Exfoliants: Another way of giving skin a more youthful look is by exfoliating the top layer of dry, dead skin to reveal fresh, new, evenly pigmented skin. Products with various hydroxy acids are relying on this exfoliating action to correct signs of aging. It’s worth noting that the antioxidant retinol also has exfoliant-like properties. Retinol helps encourage skin cells to turn over more rapidly so that you have more new skin cells and a more even skin tone.
Moisturizers: Adding moisture is a really simple way to reduce the appearance of fine lines and wrinkles. The effect is temporary though, and lasts only as long as the moisture remains in the skin cells to plump them up. One of the most powerful moisturizing ingredients is hyaluronic acid. This compound is naturally found in skin, but declines with age. Hyaluronic acid molecules can attract and retain up to 1000 times their weight in water. When applied topically, hyaluronic acid helps hydrate skin to soften the look of wrinkles.
Hormones: As the body’s chemical messengers, hormones are responsible for triggering and controlling a wide variety of processes, including the production of collagen. And of course you can’t have firm, smooth, tight, youthful-looking skin without plenty of collagen. Research has shown that applying estriol (a form of estrogen) and progesterone directly to the face can provide significant benefits for women. Wrinkles and pore size can be reduced and elasticity can be improved.
So Which Anti-Aging Cream is Right for You?
Your choice of anti-aging cream—and ultimately its effectiveness as well—will depend on what’s driving your skin changes. For menopausal women, a topical estrogen and progesterone cream is more effective than a simple moisturizer, antioxidant, or exfoliant alone because it goes to the root cause of their skin changes, namely hormonal decline.
This type of anti-aging cream is not widely available from regular doctors for several reasons. First, many doctors don’t recognize how significant a woman’s appearance can be for her well-being and so they simply ignore cosmetic issues. Secondly, doctors are often unaware of the strong body of research that supports topical hormone treatments for improving skin quality. Finally, most doctors do not use compounding pharmacies, which prevents their patients from enjoying the benefits of the mild form of estrogen (estriol) that is most effective for fighting skin aging.
Renew Youth’s anti-aging cream contains a gentle yet effective mix of estriol and progesterone to deliver noticeable improvements in skin tone, elasticity, moisture, and smoothness. This cream can be used safely without risk of affecting your overall hormonal balance.
Maximize the Effectiveness of Your Anti-Aging Cream
No matter what type of anti-aging cream you choose, you can maximize its effectiveness by following these tips
Follow Instructions: Some anti-aging creams have specific instructions for how and when to apply them for best results. In some cases not following instructions could actually be harmful. For example, products containing retinol should not be applied to wet skin or mixed with products containing benzoyl peroxide, or irritation may result.
Nourish Your Skin: Proper nutrition supplies the building blocks for healthy skin. You’ll want to limit sugary foods that can trigger glycation, while adding more of the skin-friendly nutrients that help protect against free radicals. Foods rich in Vitamins C, E, and A are considered vital for healthy skin. You could also consider taking an antioxidant supplement such as CoQ10.
Balance Your Hormones: While a topical application of estrogen and progesterone will help improve the appearance of your skin, for even greater improvement you need to address your overall hormone balance, which will drive skin changes from within. Renew Youth offers proven safe and effective hormone replacement therapy including personalized dosages of the vital hormones you may be low on during menopause, such as estrogen, progesterone, thyroid, DHEA, and testosterone. When all of these hormones are balanced at more youthful levels, your skin will look more youthful as well. Increasing production of growth hormone can also be helpful, as growth hormone is responsible for repair and renewal of cells throughout the body, including in your skin. We offer treatments that can boost production of your own natural growth hormone.
Protect Your Skin: If you use an anti-aging skin cream but continue to engage in behaviors that are damaging to skin, you likely won’t see the improvements you desire. Take common-sense steps to protect your skin, such as limiting sun exposure, wearing sunscreen, avoiding cigarette smoke, and eating a skin-friendly diet high in antioxidants.
Find Products You Can Trust at Renew Youth
If you are interested in harnessing the power of hormones to improve your skin’s appearance, contact Renew Youth today. We can offer both topical anti-aging cream for women as well as comprehensive hormone therapy. All of our treatments are based on the latest proven science and include high-quality ingredients you can trust for visible results.
The world has been abuzz about the internet of things, or IoT, for a few years now. The question, of course, is whether or not the technology will live up to its many promises. One thing’s for certain: The technology faces a lot of tough challenges in 2019. Below, American investor and former hedge fund manager Paul Mampilly addresses these challenges and some of the potential solutions that are likely to affect the trajectory of this technology in the months and years to come.
From the beginning of 2017 to September 2018, the number of connected devices, or IoT devices, grew from 35 percent to 44 percent. According to Gartner, which held its most recent ITExpo in Barcelona in November 2018, the number of connected things is predicted to hit 14.2 billion in 2019 and 25 billion by 2021. More than ever, then, it’s crucial for developers and others to address the serious challenges that are currently standing between the technology and its full potential. The two most crucial ones, according to Paul Mampilly, are security and incompatibility.
All too often, developers design IoT solutions for specific ecosystems that typically have uniquely defined ways of collecting information, communicating and otherwise operating. This is shortsighted and becoming recognized more as an issue because when IoT devices are constrained to proprietary ecosystems, as is often the case, only a limited subset of problems may be addressed. In turn, innovation slows down or stops entirely. This is unacceptable to someone like Mampilly, who came to the U.S. from India as a young man and launched his Wall Street career in 1991.
Limiting IoT devices and products to specific ecosystems is problematic for many reasons. It limits the market potential of the devices, for example, by not allowing them to easily interact with products in different ecosystems. It also can impede innovation because new concepts that would otherwise be unearthed through exposure to different ecosystems are overlooked entirely.
As Mampilly knows well through his research into the IoT, developers can and often do build support for IoT devices across multiple ecosystems. However, going about it this way poses numerous problems, including:
- by expanding the code footprint
- by further complicating security
- by complicating development in general
- by increasing the costs of development
Featured on Bloomberg TV, Fox Business News and CNBC, Paul Mampilly believes that a balance can be struck that will help the IoT to realize its full, groundbreaking potential—but a couple of things need to be done. First, developers should leverage existing open source code, IoT kits and standard languages as much as possible rather than starting from scratch every time. Additionally, they should also carry out solution checks to ensure security—they should never assume that existing technology will properly protect new IoT devices.
Speaking of security, Mampilly and many others believe that it is one of the steepest challenges that will be faced by the IoT in 2019. To address this problem, developers must clearly visualize what the IoT device that they are developing should do and put a lot of thought into the matter. For example, what can it do in the ecosystem as a whole—with other types of products? Additionally, developers must protype and test their creations diligently and often. Rapid prototyping is the key to putting concepts into action and to coming up with new ones. It also gives potential customers the chance to try out products under development and to provide valuable feedback.
Naturally, as a skilled investor and former hedge fund manager like Mampilly can attest, organizations are primarily interested in IoT for its potential for increasing profitability. However, studies have shown that only 20 percent of new potential interactions between new IoT devices and existing devices will produce new revenue. However, a snowball effect is likely to occur soon; as more companies work to scale IoT products, for example, machine learning and AI will become more crucial—and for those technologies to thrive, edge computing will become more necessary than ever.
Having grown a $6-billion hedge fund early in his career to one with assets that exceeded $25 billion under his management, Paul Mampilly knows and understands investors’ concerns regarding IoT. Lately, for example, IoT has been moving into the industrial and B2B arenas, exposing the technology to much higher risks. At this point, security has to be emphasized over innovation; otherwise, people may lose so much faith in IoT that it will fizzle out and never realize its true potential.
Fortunately for the future of IoT, however, early adopters are beginning to realize ROI thanks to their use of IoT. Rather than focusing on using the technology to address specific issues and processes, the organizations that are succeeding with it are implementing it across their entire business processes at the organizational level. A great example is found in the story of Royal Swaziland Sugar Corp., which now uses IoT throughout all of its processes, including the growth, transportation and processing of sugar cane.
After launching his career on Wall Street as an assistant portfolio manager for Bankers Trust, Mampilly progressed through important positions that involved managing multimillion-dollar accounts for organizations like ING and Deutsche Bank. He knows that for businesses to continue to thrive and to remain increasingly profitable, adoption of new and innovative technologies is often necessary. For the success of IoT, for example, the growth and increased adoption of edge computing and the cloud are more important than ever.
A major side effect of the development of IoT devices, which now run the gamut and apply to virtually every industry, is the plethora of data that is being generated on a constant basis. Getting this data under control is a vital part of the continued success of IoT, and this means moving away from centralized data centers and into edge computing, which involves carrying out computing processes on or near actual devices themselves. This reduces traffic to external servers and eliminates the need to continually add more capacity to data centers, which is a major impediment to long-term profitability.
Paul Mampilly grew tired of the Wall Street rat race and officially retired from it at the age of 41. In his new career, he now focuses on helping “Main Street Americans” to make savvy investment decisions. He primarily does this through his newsletter, Profits Unlimited, which boasts more than 130,000 subscribers and counting. Having segued seamlessly into his new role, Mampilly understands that change is inevitable—and that conventions for the IoT and human interactions are still being developed.
With a technology that virtually does away with screens and keyboards, what does the future hold for the Internet of Things? Several factors will affect the ultimate outcome, including new algorithms, new sensors, new experience architectures and context and socially aware experiences. Thus far, voice-controlled digital assistants have emerged as the biggest success of the nascent IoT revolution, but that doesn’t mean that the course is set in stone.
After all, there is truly no way to know what will become widely adopted by society and what will fall flat. The only way to realize all of the best potential of this technology, then, is by making it as interoperable and secure as possible.
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About Aloha Construction, Inc
Aloha Construction is a leading general contracting company. It is a well-known company providing services for all of Illinois and Southern Wisconsin. This firm is a family-owned and operated construction company comprising the quality team of specialists, inspectors, managers, supervisors, installers and office staff. Aloha also reaches out to its customers in Champaign, Tazewell, Washington, Peoria, and McClean counties through its Bloomington offices. The teams have worked hard together to complete over 20,000 local projects totaling over 15 million sq /ft of shingles, and 7.1 million sq/ft of Vinyl siding as well as a million linear feet of flawless gutters.
Marc Beer has proven his entrepreneurial prowess again and again with immense success. With a career that has spanned more than 25 years, Beer has brought numerous companies to the pinnacle of success for one simple reason – he is a master at developing unique workable solutions that solve immediate and pressing problems.
Beer graduated with a Bachelor of Science in Business from Miami University in 1987. This education and his innate talent prepared him for the career path he has followed since, a career path that began in pharmaceutical sales and marketing and lead to the position of Vice President of Global Marketing at Genzyme (NASDAQ: GENZ). This was a position that allowed Beer to get Genzyme out in front of the world, as he promoted the company’s product line, a product line geared toward the more than 350 million medically underserved people across the globe suffering from any of the more than 7,000 rare diseases that afflict human kind.
The experience of helping the underserved prompted Beer to consider upping his game. Beer wanted to push further, to make a difference by addressing issues that were pressing and difficult to solve in the pharmaceutical industry, and his experience up to this point had set him up perfectly to set out on his own. This is what led Marc Beer to launch his first company.
It was 2007 and Beer was on top of the world. His first venture, ViaCell, which he launched in 2000 following his time in pharmaceutical sales and marketing, had successfully blossomed into a biotechnology company that employed 300 people and went public in 2005, listing on NASDAQ as VIAC. The company specialized in the collection and preservation of umbilical cord blood stem cells for development and use to treat a variety of conditions in the human body.
In 2007, seven short years after founding the company, Beer sold ViaCell to PerkinElmer for $300 million. He had the world by the tail, with his first massive entrepreneurial success under his belt and a wonderful family full of love. Unfortunately, this is precisely when tragedy struck.
Shortly after the sale of ViaCell, Beer’s wife died suddenly from a pulmonary embolism at the age of 42. Devastated, Beer took solace in raising his three children full-time. However, just two years later, it was one of those children – his 14-year-old daughter – who told her dad that he needed to get back on the horse and start a new company. She turned the sage advice he had given her on “living with purpose” back on him, compassionately informing him that his life’s purpose was not driving her to and from school every day.
Fortunately, he listened to her advice, relaunching an entrepreneurial career that has led him to another decade of massive success, the pinnacle of which was the launch and growth of his latest company – Renovia.
Beer’s most recent climb to success has been as a co-founder, CEO, and Chairman of Renovia. The company has its roots firmly planted in a phone call Beer received from a gynecologist, Dr. Ray Iglesias, who had been performing pelvic floor surgeries for 35 years. Dr. Iglesias had spent nearly a decade trying to determine how to help women avoid surgery and he had an idea that he brought to Beer through that initial phone call – a phone call that changed Beer’s life.
In 2016, Beer partnered with Dr. Iglesias and Yolanda Lorié to found Renovia, a Boston-based med-tech company that focuses on the development of therapeutic and diagnostic devices for women with pelvic floor disorders, with the goal of providing first-line diagnosis and treatment. Pelvic floor disorders include pelvic organ prolapse, urinary incontinence, and fecal incontinence, disorders that affect close to 25% of women in the U.S.
Beer saw the number of women suffering from pelvic floor disorders as a serious issue, with ambulatory physician costs in 2005-2006 at $298 million, and one that he could directly impact. It is Beer’s intention to lead the development of Renovia to a successful combination of “innovative and proprietary sensor technologies” with a “digital health platform.”
The year 2018 has been one of milestones for Renovia. The company had its first product, Leva, approved by the Food and Drug Administration (FDA) in April. Beer’s most recent success at the helm of Renovia is the acquisition of a Series B round of funding, to the tune of $32 million, with an additional $10 million in venture funding. Series B funding has been helmed by Perceptive Advisors of New York and Ascension Ventures of Missouri. The Longwood Fund, a healthcare investment firm that has been investing in Renovia from the beginning, also contributed to Series B funding.
In a statement regarding the Series B funding, Beer said, “We are thrilled to have the support of this group of leading healthcare investors who share our vision to better diagnose, treat and improve the lives of millions of women affected by pelvic floor disorders. Combining our innovative and proprietary sensor technologies and form factors with a digital health platform will give our customers valuable data to inform new treatment options, drive greater knowledge and understanding of pelvic floor disorders, and ultimately lower long-term healthcare costs.”
The goal behind Renovia’s approach is to remove the stigma associated with discussing pelvic floor disorders, something that stops millions of women from seeking treatment for their condition. Through their line of products, Renovia strives to use their research to help diagnose and treat pelvic floor disorders, which can be caused by any of the following:
- Uterine fibroids
- Digestive diseases
- Chronic pelvic inflammatory disease
- Interstitial cystitis
Renovia’s goal is to help women who suffer with pelvic floor disorders to regain strength and control of their pelvic floor muscles through the use of FDA-approved medical devices paired with app technology and data management that are patient-based. This will allow patients to be in the driver’s seat as they improve their health and it will ultimately result in lower long-term healthcare costs for both patients and the healthcare industry.
As a part of this strategy, Marc Beer and Renovia back the Women’s Preventive Services Initiative (WPSI) and the American College of Obstetricians and Gynecologists (ACOG) in recommending that women be screened for urinary incontinence. Dr. Samantha Pulliam, Chief Medical Officer at Renovia, says, “The ACOG Committee Opinion and the WSPI screening recommendations are both so well aligned with Renovia’s commitment to awareness and first-line treatment. Both recommendations support a call-to-action related to female pelvic health, and we are excited for the positive health impact they can have for millions of women who experience urinary incontinence and other pelvic floor disorders.”
For Marc Beer, It’s All About People
All this success has not gone to Marc Beer’s head. He knows that when it comes down to it, the success he has experienced is because of the people he has worked with and the talent he has brought on board. Talent acquisition and organizational structure are the primary focus of Beer’s workday. He firmly believes if he has the right talent and leadership teams in place, everything else will take care of itself.
On top of this, Beer takes goal setting seriously. Once goals are set, resource allocation and capital efficiency can be applied, and since data collection takes place 24/7, the process of allocating resources is more efficient and cost-effective, allowing for the all-important cashflow to continue to boost the business and keep it moving in the right direction.
Marc Beer is intent on giving back to the community in ways that go beyond the scope of his work. This is why he uses his leadership and problem-solving abilities to better the lives of others. On the business side of giving back, Beer has served as a member of the Notre Dame Research and Commercialization Advisory Committee and the Graduate Studies Research and Advisory Council. In addition, he is currently a serving member of the Miami University Business Advisory Council.
On the health side of the service equation, Beer is dedicated to helping others in difficult health situations. In the past, he has served as a member of the Mass Life Science Board for the Commonwealth of Massachusetts and the Biotechnology Innovation Organization (BIO) Emerging Companies Section Governing Board. He has also served as a member of the board of directors of Erytech Pharma (NASDAQ: ERYP).
However, this is just the tip of the ice berg. Beer has also given back through his previous service on the board of directors of the Joe Andruzzi Cancer Foundation, a foundation that provides financial support for cancer patients and their families, and by getting deeply involved with Minerva Neurosciences, Inc. (NASDAQ: NERV), a company that strives to make a difference in the lives of patients who suffer from diseases of the central nervous system. For Minerva Neurosciences, Beer has served as a member of their audit committee and as the Founding Chairman of the Board and chair of the committee for compensation.
Dynamic Leadership When It’s Needed Most
Marc Beer is a highly successful entrepreneur and he has spoken about what this entails. The entrepreneurial advice he gives includes:
- Creating a financial plan
- Being willing to make sacrifices
- Focusing on winning
- Remaining logical
- Learning from failure
- Enjoying the entrepreneurial process
- Giving back to the community
Beer has followed this advice throughout his life, committing himself improving the lives of medical practitioners and their patients by providing leadership and ingenious problem-solving skills to bridge the gap between problems and workable solutions. This has been evident with his success in building ViaCell and he has repeated that success with his current company, Renovia. He is an invaluable member of and leader in the biotech business community.